Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Acadl. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

This gene encodes a homotetrameric mitochondrial flavoprotein and is a member of the acyl-CoA dehydrogenase family. Members of this family catalyze the first step of fatty acid beta-oxidation, forming a C2-C3 trans-double bond in a FAD-dependent reaction. As beta-oxidation cycles through its four steps, each member of the acyl-CoA dehydrogenase family works at an optimum fatty acid chain-length. This enzyme has its optimum length between C12- and C16-acylCoA. In mice, deficiency of this gene can cause sudden death, cardiomyopathy as well as fasting and cold intolerance. [provided by RefSeq, Nov 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Acadl
  • is located in the following cellular components:
    • mitochondrion ^{[3, 4]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Acadl
  • participates in the following biological processes:
    • carnitine catabolic process ^[2]
    • carnitine metabolic process, CoA-linked ^[2]
    • cellular lipid catabolic process ^[2]
    • fatty acid beta-oxidation using acyl-CoA dehydrogenase ^[1]
    • negative regulation of fatty acid biosynthetic process ^[1]
    • negative regulation of fatty acid oxidation ^[1]
    • oxidation-reduction process ^[2]
    • regulation of cholesterol metabolic process ^[1]
    • temperature homeostasis ^[1]
  • performs the following molecular functions:
    • long-chain-acyl-CoA dehydrogenase activity ^[2]
    • palmitoyl-CoA oxidase activity ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Acadl:
  • participates in the following biological processes:
    • fatty acid beta-oxidation using acyl-CoA dehydrogenase
    • long-chain fatty acid catabolic process
    • protein homotetramerization
  • performs the following molecular functions:
    • fatty-acyl-CoA binding
    • flavin adenine dinucleotide binding
    • long-chain-acyl-CoA dehydrogenase activity
  • is located in the following cellular components:
    • cytoplasm
    • mitochondrial matrix
    • mitochondrial membrane
    • mitochondrion

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Summary text based on GO annotations supported by structural data

• Acadl encodes a protein or proteins that contain the following InterPro domains: Acyl-CoA dehydrogenase, conserved site, Acyl-CoA dehydrogenase, N-terminal, Acyl-CoA dehydrogenase/oxidase, Acyl-CoA dehydrogenase/oxidase C-terminal, Acyl-CoA dehydrogenase/oxidase, N-terminal, Acyl-CoA oxidase/dehydrogenase, central domain, Acyl-CoA oxidase/dehydrogenase, type 1, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • acyl-CoA dehydrogenase activity
    • oxidoreductase activity, acting on the CH-CH group of donors

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Acadl indicates that it:
  • participates in the following biological processes:
    • fatty acid metabolic process
    • lipid metabolic process
    • oxidation-reduction process
  • performs the following molecular functions:
    • oxidoreductase activity

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References

1. Goetzman ES et al. (2005) Differential induction of genes in liver and brown adipose tissue regulated by peroxisome proliferator-activated receptor-alpha during fasting and cold exposure in acyl-CoA dehydrogenase-deficient mice. Mol Genet Metab, 84:39-47. (PubMed:15639194)
2. Kurtz DM et al. (1998) Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation. Proc Natl Acad Sci U S A, 95:15592-7. (PubMed:9861014)
3. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
4. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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