Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pzp. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pzp
  • participates in the following biological processes:
    • negative regulation of endopeptidase activity ^[1]
  • performs the following molecular functions:
    • endopeptidase inhibitor activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pzp:
  • performs the following molecular functions:
    • protein complex binding
  • is located in the following cellular components:
    • extracellular vesicular exosome

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Summary text based on GO annotations supported by structural data

• Pzp encodes a protein or proteins that contain the following InterPro domains: A-macroglobulin complement component, Alpha-2-macroglobulin, Alpha-2-macroglobulin, conserved site, Alpha-2-macroglobulin, N-terminal, Alpha-2-macroglobulin, N-terminal 2, Alpha-2-macroglobulin, thiol-ester bond-forming, Alpha-macroglobulin, receptor-binding, Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid, indicating that the gene product:
  • is located in the following cellular components:
    • extracellular space

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pzp indicates that it:
  • participates in the following biological processes:
    • negative regulation of endopeptidase activity
    • negative regulation of peptidase activity
  • performs the following molecular functions:
    • peptidase inhibitor activity
    • serine-type endopeptidase inhibitor activity

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References

1. Greene ND et al. (1971) The identification of alpha-2-macroglobulin in the mouse. Biochim Biophys Acta, 236:659-63. (PubMed:5559967)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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