Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of a. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of a has been shown to bind to the gene products of Atrn. ^[3] Researchers have inferred, based on physical interactions, that the gene product of a
  • performs the following molecular functions:
    • melanocortin receptor binding ^[5]
    • type 3 melanocortin receptor binding ^[5]
    • type 4 melanocortin receptor binding ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of a
  • participates in the following biological processes:
    • adult feeding behavior ^[1]
    • genetic imprinting ^[8]
    • melanin biosynthetic process ^[7]
    • melanosome organization ^[4]
    • melanosome transport ^[4]
    • pigmentation ^[6]
    • regulation of molecular function, epigenetic ^[8]
• Researchers have inferred, based on genetic interactions, that the gene product of a
  • participates in the following biological processes:
    • adult feeding behavior based on interactions with Dmbx1 ^[1]
    • generation of precursor metabolites and energy based on interactions with Vgf ^[2]

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Summary text based on GO annotations supported by structural data

• a encodes a protein or proteins that contain the following InterPro domains: Agouti, indicating that the gene product:
  • participates in the following biological processes:
    • hormone-mediated signaling pathway
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe a indicates that it:
  • is located in the following cellular components:
    • extracellular region

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References

1. Fujimoto W et al. (2007) Dmbx1 is essential in agouti-related protein action. Proc Natl Acad Sci U S A, 104:15514-9. (PubMed:17873059)
2. Hahm S et al. (2002) VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting. J Neurosci, 22:6929-38. (PubMed:12177191)
3. He L et al. (2001) A biochemical function for attractin in agouti-induced pigmentation and obesity. Nat Genet, 27:40-7. (PubMed:11137996)
4. Hirobe T et al. (1998) Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture. Eur J Cell Biol, 75:184-91. (PubMed:9548375)
5. Kiefer LL et al. (1998) Melanocortin receptor binding determinants in the agouti protein. Biochemistry, 37:991-7. (PubMed:9454589)
6. Markert CL et al. (1956) The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics, 41:429-50. (PubMed:17247639)
7. Ozeki H et al. (1995) Chemical characterization of hair melanins in various coat-color mutants of mice. J Invest Dermatol, 105:361-6. (PubMed:7665913)
8. Rakyan VK et al. (2003) Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A, 100:2538-43. (PubMed:12601169)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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