Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Skor2. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of June 5, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Skor2
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter ^{[1, 2]}
  • performs the following molecular functions:
    • transcription corepressor activity ^[1]
  • is located in the following cellular components:
    • nucleus ^{[1, 2]}
• Researchers have inferred, based on physical interactions, that the gene product of Skor2
  • performs the following molecular functions:
    • histone deacetylase binding ^[2]
    • SMAD binding ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Skor2
  • participates in the following biological processes:
    • cerebellar Purkinje cell differentiation ^[2]
    • cerebellum morphogenesis ^[2]
    • positive regulation of smoothened signaling pathway ^[2]
    • regulation of cerebellar granule cell precursor proliferation ^[2]
    • regulation of dendrite morphogenesis ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Skor2
  • participates in the following biological processes:
    • negative regulation of BMP signaling pathway based on interactions with Bmp2 ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Skor2:
  • participates in the following biological processes:
    • negative regulation of transforming growth factor beta receptor signaling pathway
  • performs the following molecular functions:
    • SMAD binding
  • is located in the following cellular components:
    • cytoplasm
    • nucleus

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Summary text based on GO annotations supported by structural data

• Skor2 encodes a protein or proteins that contain the following InterPro domains: c-SKI SMAD4-binding domain, DNA binding domain, putative, SAND domain-like, Transcription regulator SKI/SnoN, Transforming protein Ski, indicating that the gene product:
  • performs the following molecular functions:
    • nucleotide binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Skor2 indicates that it:
  • participates in the following biological processes:
    • regulation of transcription, DNA-dependent
    • transcription, DNA-dependent

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References

1. Minaki Y et al. (2008) Identification of a novel transcriptional corepressor, Corl2, as a cerebellar Purkinje cell-selective marker. Gene Expr Patterns, 8:418-23. (PubMed:18522874)
2. Wang B et al. (2011) Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development, 138:4487-97. (PubMed:21937600)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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