Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. A structural constituent of postsynaptic density. Involved in several processes, including dendritic spine morphogenesis; learning or memory; and righting reflex. Acts upstream of or within negative regulation of actin filament bundle assembly. Located in several cellular components, including dendritic spine; excitatory synapse; and postsynaptic density. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex; frontal cortex; and neocortex region. Orthologous to human SHANK1 (SH3 and multiple ankyrin repeat domains 1).