Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnh5. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. This gene is not expressed in differentiating myoblasts. Alternative splicing results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcnh5:
  • participates in the following biological processes:
    • regulation of G2/M transition of mitotic cell cycle
  • is located in the following cellular components:
    • cell surface
    • intracellular

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Summary text based on GO annotations supported by structural data

• Kcnh5 encodes a protein or proteins that contain the following InterPro domains: Cyclic nucleotide-binding domain, Cyclic nucleotide-binding-like, Ion transport domain, PAC motif, PAS domain, PAS-associated, C-terminal, Potassium channel, voltage-dependent, EAG, Potassium channel, voltage-dependent, EAG/ELK/ERG, RmlC-like jelly roll fold, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • phosphorelay signal transduction system
    • potassium ion transport
    • protein phosphorylation
    • regulation of transcription, DNA-dependent
    • signal transduction
    • signal transduction by phosphorylation
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
    • phosphorelay sensor kinase activity
    • signal transducer activity
    • voltage-gated potassium channel activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnh5 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transmembrane transport
    • potassium ion transport
    • regulation of ion transmembrane transport
    • transport
  • performs the following molecular functions:
    • calmodulin binding
    • ion channel activity
    • potassium channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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