Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kcnh5. (This text reflects annotations as of Thursday, January 16, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of voltage-gated potassium channels. Members of this family have diverse functions, including regulating neurotransmitter and hormone release, cardiac function, and cell volume. This protein is an outward-rectifying, noninactivating channel. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kcnh5:
  • participates in the following biological processes:
    • potassium ion transmembrane transport
    • regulation of G2/M transition of mitotic cell cycle
    • regulation of ion transmembrane transport
    • regulation of membrane potential
  • performs the following molecular functions:
    • voltage-gated potassium channel activity
  • is located in the following cellular components:
    • cell surface
    • integral component of plasma membrane
    • intracellular

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Summary text based on GO annotations supported by structural data

• Kcnh5 encodes a protein or proteins that contain the following InterPro domains: Cyclic nucleotide-binding domain, Cyclic nucleotide-binding-like, Ion transport domain, PAC motif, PAS domain, PAS-associated, C-terminal, Potassium channel, voltage-dependent, EAG, Potassium channel, voltage-dependent, EAG/ELK/ERG, RmlC-like jelly roll fold, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • phosphorelay signal transduction system
    • potassium ion transport
    • signal transduction
    • transmembrane transport
  • performs the following molecular functions:
    • ion channel activity
    • phosphorelay sensor kinase activity
    • signal transducer activity
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Kcnh5 indicates that it:
  • participates in the following biological processes:
    • ion transport
    • potassium ion transport
    • transport
  • performs the following molecular functions:
    • calmodulin binding
    • potassium channel activity
    • voltage-gated ion channel activity
  • is located in the following cellular components:
    • integral component of membrane
    • membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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