Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits cysteine-type peptidase activity and thiol-dependent ubiquitin-specific protease activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of signal transduction. Localizes to cytoplasm. Colocalizes with LUBAC complex. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in otulipenia. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity).