Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Iqsec2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked mental retardation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Iqsec2:
  • participates in the following biological processes:
    • actin cytoskeleton organization
  • performs the following molecular functions:
    • ARF guanyl-nucleotide exchange factor activity
  • is located in the following cellular components:
    • cell junction
    • nucleus

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Summary text based on GO annotations supported by structural data

• Iqsec2 encodes a protein or proteins that contain the following InterPro domains: IQ motif, EF-hand binding site, Pleckstrin homology domain, Pleckstrin homology-like domain, SEC7-like, SEC7-like, alpha orthogonal bundle, indicating that the gene product:
  • participates in the following biological processes:
    • regulation of ARF protein signal transduction
  • performs the following molecular functions:
    • phospholipid binding
  • is located in the following cellular components:
    • intracellular

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Iqsec2 indicates that it:
  • is located in the following cellular components:
    • cytoplasm

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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