Automated description from the Alliance of Genome Resources (Release 3.2)
Predicted to have NAD(P)H oxidase H2O2-forming activity; calcium ion binding activity; and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including animal organ development; fertilization; and thyroid hormone metabolic process. Predicted to localize to several cellular components, including NADPH oxidase complex; cell leading edge; and cell surface. Is expressed in placenta and thyroid gland. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism. Orthologous to human DUOX2 (dual oxidase 2).