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Gene Ontology Classifications
histone deacetylase 4

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GO curators for mouse genes have assigned the following annotations to the gene product of Hdac4. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of September 10, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ago T et al. (2008) A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell, 133:978-93. (PubMed:18555775)
  2. Arnold MA et al. (2007) MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell, 12:377-89. (PubMed:17336904)
  3. Backs J et al. (2008) Histone deacetylase 5 acquires calcium/calmodulin-dependent kinase II responsiveness by oligomerization with histone deacetylase 4. Mol Cell Biol, 28:3437-45. (PubMed:18332106)
  4. Berdeaux R et al. (2007) SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med, 13:597-603. (PubMed:17468767)
  5. Cao D et al. (2005) Modulation of smooth muscle gene expression by association of histone acetyltransferases and deacetylases with myocardin. Mol Cell Biol, 25:364-76. (PubMed:15601857)
  6. Cohen TJ et al. (2007) The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem, 282:33752-9. (PubMed:17873280)
  7. Dai YS et al. (2005) The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol, 25:9936-48. (PubMed:16260608)
  8. Gupta MP et al. (2008) HDAC4 and PCAF bind to cardiac sarcomeres and play a role in regulating myofilament contractile activity. J Biol Chem, 283:10135-46. (PubMed:18250163)
  9. Heverin M et al. (2007) Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol. Arterioscler Thromb Vasc Biol, 27:2191-7. (PubMed:17761942)
  10. Izzi L et al. (2007) Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J, 26:3132-43. (PubMed:17568773)
  11. Jeong BC et al. (2004) Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase. Mol Endocrinol, 18:13-25. (PubMed:14576337)
  12. Kang JS et al. (2005) Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3. EMBO J, 24:2543-55. (PubMed:15990875)
  13. Lemercier C et al. (2000) mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity. J Biol Chem, 275:15594-9. (PubMed:10748098)
  14. Luan B et al. (2014) Leptin-mediated increases in catecholamine signaling reduce adipose tissue inflammation via activation of macrophage HDAC4. Cell Metab, 19:1058-65. (PubMed:24768298)
  15. Pan Z et al. (2008) Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice. Dev Dyn, 237:316-27. (PubMed:18163532)
  16. Potthoff MJ et al. (2007) Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest, 117:2459-67. (PubMed:17786239)
  17. Sasagawa S et al. (2012) SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice. Development, 139:1153-63. (PubMed:22318228)
  18. Tang H et al. (2009) A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Mol Biol Cell, 20:1120-31. (PubMed:19109424)
  19. Vega RB et al. (2004) Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell, 119:555-66. (PubMed:15537544)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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