Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits PDZ domain binding activity and ionotropic glutamate receptor binding activity. Involved in several processes, including excitatory chemical synaptic transmission; postsynaptic neurotransmitter receptor diffusion trapping; and regulation of signal transduction. Localizes to AMPA glutamate receptor complex; asymmetric, glutamatergic, excitatory synapse; and integral component of postsynaptic density membrane. Is expressed in central nervous system. Orthologous to human SHISA6 (shisa family member 6).