Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits peroxisome proliferator activated receptor binding activity; retinoic acid receptor binding activity; and transcription coactivator activity. Involved in several processes, including animal organ development; negative regulation of fat cell differentiation; and regulation of signal transduction. Localizes to nucleus. Predicted to colocalize with nuclear chromatin. Is expressed in several structures, including limb bud; lung; nervous system; paraxial mesenchyme; and salivary gland. Used to study acute myeloid leukemia; myelodysplastic syndrome; and myeloproliferative neoplasm. Human ortholog(s) of this gene implicated in SM-AHNMD; acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myelofibrosis. Orthologous to human ASXL1 (ASXL transcriptional regulator 1).