Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ift172. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 3, 2006. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ift172
  • is located in the following cellular components:
    • cilium ^[3]
• The gene product of Ift172 has been shown to bind to the gene products of Ift88. ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ift172
  • participates in the following biological processes:
    • cilium assembly ^{[3, 4]}
    • determination of left/right symmetry ^[1]
    • dorsal/ventral pattern formation ^{[1, 3, 4]}
    • neural tube formation ^[3]
    • protein processing ^[2]
    • smoothened signaling pathway ^[5]
    • spinal cord motor neuron differentiation ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Ift172
  • participates in the following biological processes:
    • dorsal/ventral pattern formation based on interactions with Smo ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ift172:
  • participates in the following biological processes:
    • negative regulation of transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • transcription factor binding
  • is located in the following cellular components:
    • microtubule basal body
    • microtubule-based flagellum
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ift172 indicates that it:
  • participates in the following biological processes:
    • multicellular organismal development
  • is located in the following cellular components:
    • cell projection

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References

1. Garcia-Garcia MJ et al. (2005) Inaugural Article: Analysis of mouse embryonic patterning and morphogenesis by forward genetics. Proc Natl Acad Sci U S A, 102:5913-9. (PubMed:15755804)
2. Huangfu D et al. (2005) Cilia and Hedgehog responsiveness in the mouse. Proc Natl Acad Sci U S A, 102:11325-30. (PubMed:16061793)
3. Huangfu D et al. (2003) Hedgehog signalling in the mouse requires intraflagellar transport proteins. Nature, 426:83-7. (PubMed:14603322)
4. Ocbina PJ et al. (2011) Complex interactions between genes controlling trafficking in primary cilia. Nat Genet, 43:547-53. (PubMed:21552265)
5. Pazour GJ et al. (2000) Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella J Cell Biol, 151:709-18. (PubMed:11062270)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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