Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process. Acts upstream of or within several processes, including positive regulation of smoothened signaling pathway; skeletal system development; and sulfation. Is active in Golgi apparatus. Is expressed in several structures, including alimentary system; brain; ear; respiratory system; and skeletal system. Human ortholog(s) of this gene implicated in temtamy preaxial brachydactyly syndrome. Orthologous to human CHSY1 (chondroitin sulfate synthase 1).