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Gene Ontology Classifications
Symbol
Name
ID
Satb2
special AT-rich sequence binding protein 2
MGI:2679336

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GO curators for mouse genes have assigned the following annotations to the gene product of Satb2. (This text reflects annotations as of Thursday, July 24, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 4, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Arnold SJ et al. (2008) The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev, 22:2479-84. (PubMed:18794345)
  2. Britanova O et al. (2008) Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron, 57:378-92. (PubMed:18255031)
  3. Britanova O et al. (2006) Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development. Am J Hum Genet, 79:668-78. (PubMed:16960803)
  4. Britanova O et al. (2005) Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS. Eur J Neurosci, 21:658-68. (PubMed:15733084)
  5. Dobreva G et al. (2006) SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation. Cell, 125:971-86. (PubMed:16751105)
  6. Srinivasan K et al. (2012) A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc Natl Acad Sci U S A, 109:19071-8. (PubMed:23144223)
  7. Wilanowski T et al. (2008) Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. EMBO J, 27:886-97. (PubMed:18288204)



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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory