Automated description from the Alliance of Genome Resources
Exhibits RNA polymerase II proximal promoter sequence-specific DNA binding activity and chromatin binding activity. Involved in several processes, including generation of neurons; regulation of transcription by RNA polymerase II; and skeletal system development. Localizes to the histone deacetylase complex and transcription factor complex. Used to study isolated cleft palate. Human ortholog(s) of this gene implicated in chromosome 2q32-q33 deletion syndrome. Is expressed in several structures, including 1st branchial arch; alimentary system; cerebral cortex; genitourinary system; and limb. Orthologous to human SATB2 (SATB homeobox 2).