Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and chromatin binding activity. Acts upstream of or within several processes, including osteoblast development; regulation of transcription by RNA polymerase II; and skeletal system development. Located in nucleus. Part of histone deacetylase complex and transcription regulator complex. Is expressed in several structures, including 1st branchial arch; cerebral cortex; facial prominence; genitourinary system; and limb. Used to study isolated cleft palate. Human ortholog(s) of this gene implicated in SATB2-associated syndrome. Orthologous to human SATB2 (SATB homeobox 2).