Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Kiss1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a metastasis suppressor gene that suppresses metastases of melanomas and breast carcinomas without affecting tumorigenicity. The encoded protein may inhibit chemotaxis and invasion and thereby attenuate metastasis in malignant melanomas. Studies suggest a putative role in the regulation of events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization. A protein product of this gene, kisspeptin, stimulates gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion and regulates the pubertal activation of GnRH nuerons. A polymorphism in the terminal exon of this mRNA results in two protein isoforms. An adenosine present at the polymorphic site represents the third position in a stop codon. When the adenosine is absent, a downstream stop codon is utilized and the encoded protein extends for an additional seven amino acid residues. [provided by RefSeq, Mar 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Kiss1
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway ^[1]
• Researchers have inferred, based on physical interactions, that the gene product of Kiss1
  • participates in the following biological processes:
    • negative regulation of cell migration ^[1]
    • negative regulation of cell proliferation ^[1]
  • performs the following molecular functions:

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Kiss1:
  • participates in the following biological processes:
    • elevation of cytosolic calcium ion concentration
    • elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
    • generation of ovulation cycle rhythm
    • negative regulation of cell proliferation
    • positive regulation of growth hormone secretion
    • positive regulation of luteinizing hormone secretion
    • positive regulation of MAPK cascade
    • positive regulation of synaptic transmission
  • performs the following molecular functions:
    • kisspeptin receptor binding
  • is located in the following cellular components:
    • apical plasma membrane
    • cytoplasm
    • extracellular space
    • neuron projection
    • neuronal cell body

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References

1. Stafford LJ et al. (2002) Identification and characterization of mouse metastasis-suppressor KiSS1 and its G-protein-coupled receptor. Cancer Res, 62:5399-404. (PubMed:12359743)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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