Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Adcy10. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Genetic variations in this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Adcy10
  • is located in the following cellular components:
    • membrane ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Adcy10:
  • participates in the following biological processes:
    • cAMP biosynthetic process
    • positive regulation of apoptotic process
  • performs the following molecular functions:
    • adenylate cyclase activity
    • ATPase binding
    • manganese ion binding
  • is located in the following cellular components:
    • apical part of cell
    • axon
    • basal part of cell
    • cytoplasm
    • cytosol
    • dendrite
    • growth cone
    • neuronal cell body

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Summary text based on GO annotations supported by structural data

• Adcy10 encodes a protein or proteins that contain the following InterPro domains: Adenylate cylcase, type 10, Adenylyl cyclase class-3/4/guanylyl cyclase, P-loop containing nucleoside triphosphate hydrolase, indicating that the gene product:
  • participates in the following biological processes:
    • cyclic nucleotide biosynthetic process
    • intracellular signal transduction
    • spermatogenesis
  • performs the following molecular functions:
    • magnesium ion binding
    • phosphorus-oxygen lyase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Adcy10 indicates that it:
  • performs the following molecular functions:
    • ATP binding
    • lyase activity
    • metal ion binding
    • nucleotide binding
  • is located in the following cellular components:
    • cytoskeleton
    • plasma membrane

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References

1. Miranda PV et al. (2009) Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm. Biol Reprod, 80:897-904. (PubMed:19144954)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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