Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Rbm28. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a specific nucleolar component of the spliceosomal small nuclear ribonucleoprotein (snRNP)complexes . It specifically associates with U1, U2, U4, U5, and U6 small nuclear RNAs (snRNAs), possibly coordinating their transition through the nucleolus. Mutation in this gene causes alopecia, progressive neurological defects, and endocrinopathy (ANE syndrome), a pleiotropic and clinically heterogeneous disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Rbm28:
  • is located in the following cellular components:
    • Golgi apparatus
    • nucleolus

---

Summary text based on GO annotations supported by structural data

• Rbm28 encodes a protein or proteins that contain the following InterPro domains: Nucleotide-binding, alpha-beta plait, RNA recognition motif domain, indicating that the gene product:
  • performs the following molecular functions:
    • nucleic acid binding
    • nucleotide binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Rbm28 indicates that it:
  • participates in the following biological processes:
    • mRNA processing
    • RNA splicing
  • performs the following molecular functions:
    • RNA binding
  • is located in the following cellular components:
    • nucleus
    • spliceosomal complex
• Annotations directly to for the gene Rbm28 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---