Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables guanyl-nucleotide exchange factor activity. Involved in endothelial cell chemotaxis and regulation of protein catabolic process at presynapse, modulating synaptic transmission. Acts upstream of or within endothelial cell migration. Located in several cellular components, including cell-cell junction; endocytic vesicle; and lamellipodium. Is expressed in brain and cardiovascular system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5).