Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits Rho guanyl-nucleotide exchange factor activity. Involved in endothelial cell chemotaxis and regulation of protein catabolic process at presynapse, modulating synaptic transmission. Localizes to several cellular components, including cell-cell junction; endocytic vesicle; and lamellipodium. Is expressed in brain and cardiovascular system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C and distal spinal muscular atrophy type 4. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5).