Automated description from the Alliance of Genome Resources
Exhibits Rho guanyl-nucleotide exchange factor activity. Involved in endothelial cell chemotaxis and regulation of protein catabolic process at presynapse, modulating synaptic transmission. Localizes to several cellular components, including the endocytic vesicle; lamellipodium; and plasma membrane. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease recessive intermediate C. Orthologous to human PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5).