Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Tph2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Tph2
  • participates in the following biological processes:
    • oxidation-reduction process ^[3]
  • performs the following molecular functions:
    • tryptophan 5-monooxygenase activity ^[3]
  • is located in the following cellular components:
    • neuron projection ^[2]
• Based on the experimental annotations above, MGI curators have inferred, that the gene product of Tph2
  • participates in the following biological processes:
    • serotonin biosynthetic process from tryptophan ^[1]

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Summary text based on GO annotations supported by structural data

• Tph2 encodes a protein or proteins that contain the following InterPro domains: ACT domain, Aromatic amino acid hydroxylase, Aromatic amino acid hydroxylase, C-terminal, Aromatic amino acid hydroxylase, iron/copper binding site, Tryptophan 5-monooxygenase, Tyrosine 3-monooxygenase-like, indicating that the gene product:
  • participates in the following biological processes:
    • aromatic amino acid family metabolic process
    • metabolic process
    • serotonin biosynthetic process
  • performs the following molecular functions:
    • amino acid binding
    • iron ion binding
    • monooxygenase activity
    • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Tph2 indicates that it:
  • participates in the following biological processes:
    • serotonin biosynthetic process
  • performs the following molecular functions:
    • metal ion binding
    • monooxygenase activity
    • oxidoreductase activity

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References

1. Kirby PJ et al. (2002) Cloning and mapping of platypus SOX2 and SOX14: insights into SOX group B evolution. Cytogenet Genome Res, 98:96-100. (PubMed:12584449)
2. Quina LA et al. (2009) Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. J Neurosci, 29:14309-22. (PubMed:19906978)
3. Walther DJ et al. (2003) Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science, 299:76. (PubMed:12511643)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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