Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables vitamin D3 25-hydroxylase activity. Acts upstream of or within calcitriol biosynthetic process from calciol. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in embryo; hepatic primordium; liver; and testis. Human ortholog(s) of this gene implicated in artery disease (multiple); brain infarction; obesity; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1B. Orthologous to human CYP2R1 (cytochrome P450 family 2 subfamily R member 1).