Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of A2m. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of A2m
  • participates in the following biological processes:
    • stem cell differentiation ^[2]
• The gene product of A2m has been shown to bind to the gene products of Lrp1. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of A2m:
  • participates in the following biological processes:
    • negative regulation of complement activation, lectin pathway
    • negative regulation of endopeptidase activity
  • performs the following molecular functions:
    • calcium-dependent protein binding
    • endopeptidase inhibitor activity
    • enzyme binding
    • growth factor binding
    • interleukin-1 binding
    • interleukin-8 binding
    • protease binding
    • receptor binding
    • serine-type endopeptidase inhibitor activity
    • tumor necrosis factor binding
  • is located in the following cellular components:
    • blood microparticle
    • extracellular vesicular exosome

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Summary text based on GO annotations supported by structural data

• A2m encodes a protein or proteins that contain the following InterPro domains: A-macroglobulin complement component, Alpha-2-macroglobulin, Alpha-2-macroglobulin, conserved site, Alpha-2-macroglobulin, N-terminal, Alpha-2-macroglobulin, N-terminal 2, Alpha-2-macroglobulin, thiol-ester bond-forming, Alpha-macroglobulin, receptor-binding, Immunoglobulin E-set, Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid, indicating that the gene product:
  • is located in the following cellular components:
    • extracellular region
    • extracellular space

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe A2m indicates that it:
  • participates in the following biological processes:
    • female pregnancy
  • is located in the following cellular components:
    • extracellular region

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References

1. Liu Q et al. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron, 56:66-78. (PubMed:17920016)
2. Nishiyama A et al. (2009) Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell, 5:420-33. (PubMed:19796622)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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