Automated description from the Alliance of Genome Resources (Release 3.2)
Predicted to have several functions, including cytokine binding activity; growth factor binding activity; and serine-type endopeptidase inhibitor activity. Involved in stem cell differentiation. Predicted to localize to extracellular space. Is expressed in several structures, including brain; embryo mesenchyme; liver; meninges; and retina. Human ortholog(s) of this gene implicated in COVID-19; background diabetic retinopathy; neurodegenerative disease (multiple); and obstructive lung disease. Orthologous to human A2M (alpha-2-macroglobulin).