Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cxcr1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cxcr1:
  • participates in the following biological processes:
    • cell surface receptor signaling pathway
    • chemokine-mediated signaling pathway
    • G-protein coupled receptor signaling pathway
    • interleukin-8-mediated signaling pathway
    • receptor internalization
  • performs the following molecular functions:
    • interleukin-8 binding
    • interleukin-8 receptor activity

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Summary text based on GO annotations supported by structural data

• Cxcr1 encodes a protein or proteins that contain the following InterPro domains: CXC chemokine receptor/Interleukin-8 receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, indicating that the gene product:
  • participates in the following biological processes:
    • chemotaxis
    • elevation of cytosolic calcium ion concentration
    • negative regulation of cAMP biosynthetic process
  • performs the following molecular functions:
    • C-X-C chemokine receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cxcr1 indicates that it:
  • participates in the following biological processes:
    • chemotaxis
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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