Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable cullin family protein binding activity and ubiquitin ligase-substrate adaptor activity. Involved in several processes, including potassium ion homeostasis; protein polyubiquitination; and renal sodium ion absorption. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytosol. Is expressed in endocrine gland; genitourinary system; heart; lung; and nervous system. Used to study pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3).