Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nlgn3. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 15, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nlgn3
  • participates in the following biological processes:
    • positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ^[2]
    • positive regulation of excitatory postsynaptic membrane potential ^[2]
    • positive regulation of synaptic transmission, glutamatergic ^[2]
    • postsynaptic membrane assembly ^[2]
    • regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity ^[1]
    • regulation of dendritic spine morphogenesis ^[1]
    • regulation of excitatory postsynaptic membrane potential ^[1]
    • regulation of inhibitory postsynaptic membrane potential ^{[1, 4]}
    • regulation of long-term synaptic potentiation ^[1]
    • regulation of N-methyl-D-aspartate selective glutamate receptor activity ^[1]
    • regulation of synaptic transmission, glutamatergic ^[1]
    • regulation of terminal button organization ^[1]
    • social behavior ^{[1, 4]}
    • visual learning ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Nlgn3
  • participates in the following biological processes:
    • regulation of respiratory gaseous exchange by neurological system process based on interactions with Nlgn1, Nlgn2 ^[5]
    • regulation of synaptic transmission based on interactions with Nlgn1, Nlgn2 ^[5]
    • synapse organization based on interactions with Lrrtm1, Lrrtm2, Nlgn1 ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Nlgn3:
  • participates in the following biological processes:
    • axon extension
    • neuron cell-cell adhesion
    • positive regulation of synapse assembly
    • presynaptic membrane assembly
    • receptor-mediated endocytosis
    • regulation of inhibitory postsynaptic membrane potential
    • rhythmic synaptic transmission
    • social behavior
    • synapse assembly
    • synapse organization
  • performs the following molecular functions:
    • cell adhesion molecule binding
    • neurexin family protein binding
    • receptor activity
  • is located in the following cellular components:
    • cell surface
    • cytoplasm
    • endocytic vesicle
    • excitatory synapse
    • integral to plasma membrane
    • synapse

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Summary text based on GO annotations supported by structural data

• Nlgn3 encodes a protein or proteins that contain the following InterPro domains: Carboxylesterase type B, conserved site, Carboxylesterase, type B, Neuroligin, indicating that the gene product:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nlgn3 indicates that it:
  • participates in the following biological processes:
    • cell adhesion
  • is located in the following cellular components:
    • cell junction
    • integral to membrane
    • membrane
    • plasma membrane

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References

1. Etherton M et al. (2011) Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function. Proc Natl Acad Sci U S A, 108:13764-9. (PubMed:21808020)
2. Etherton MR et al. (2011) An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor-mediated synaptic transmission in hippocampus. EMBO J, 30:2908-19. (PubMed:21642956)
3. Ko J et al. (2011) Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol, 194:323-34. (PubMed:21788371)
4. Tabuchi K et al. (2007) A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice. Science, 318:71-6. (PubMed:17823315)
5. Varoqueaux F et al. (2006) Neuroligins determine synapse maturation and function. Neuron, 51:741-54. (PubMed:16982420)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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