Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cadps2. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cadps2
  • participates in the following biological processes:
    • positive regulation of exocytosis ^[4]
  • is located in the following cellular components:
    • cytoplasmic membrane-bounded vesicle ^[4]
    • cytoplasmic vesicle ^[3]
    • postsynaptic membrane ^[4]
    • presynaptic membrane ^[4]
• The gene product of Cadps2 has been shown to bind to the gene products of Dmd. ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Cadps2
  • participates in the following biological processes:
    • synaptic vesicle priming based on interactions with Cadps ^[1]

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Summary text based on GO annotations supported by structural data

• Cadps2 encodes a protein or proteins that contain the following InterPro domains: C2 calcium-dependent membrane targeting, C2 calcium/lipid-binding domain, CaLB, Calcium-dependent secretion activator, Munc13 homology 1, Pleckstrin homology domain, Pleckstrin homology-like domain, indicating that the gene product:
  • performs the following molecular functions:
    • phospholipid binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cadps2 indicates that it:
  • participates in the following biological processes:
    • exocytosis
    • protein transport
    • transport
  • performs the following molecular functions:
    • lipid binding
    • metal ion binding
  • is located in the following cellular components:
    • cell junction
    • membrane
    • synapse

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References

1. Burgalossi A et al. (2010) SNARE protein recycling by alphaSNAP and betaSNAP supports synaptic vesicle priming. Neuron, 68:473-87. (PubMed:21040848)
2. Cisternas FA et al. (2003) Cloning and characterization of human CADPS and CADPS2, new members of the Ca(2+)-dependent activator for secretion protein family. Genomics, 81:279-91. (PubMed:12659812)
3. Dubois SP et al. (2005) Survival adjustment of mature dendritic cells by IL-15. Proc Natl Acad Sci U S A, 102:8662-7. (PubMed:15932944)
4. Sadakata T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci, 24:43-52. (PubMed:14715936)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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