Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables methylcytosine dioxygenase activity. Involved in myeloid cell differentiation; positive regulation of transcription by RNA polymerase II; and protein modification process. Acts upstream of or within several processes, including hematopoietic or lymphoid organ development; hematopoietic stem cell homeostasis; and liver morphogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; extraembryonic component; lower urogenital tract; reproductive system; and urethra epithelium. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).