Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ttll1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of November 14, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Ttll1 has been shown to bind to the gene products of Tpgs1. ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ttll1
  • participates in the following biological processes:
    • cilium axoneme assembly ^[2]
    • cilium morphogenesis ^{[2, 3]}
    • epithelial cilium movement ^{[2, 3]}
    • flagellum organization ^[2]
    • protein polyglutamylation ^[2]

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Summary text based on GO annotations supported by structural data

• Ttll1 encodes a protein or proteins that contain the following InterPro domains: ATP-grasp fold, subdomain 2, Tubulin-tyrosine ligase, indicating that the gene product:
  • participates in the following biological processes:
    • cellular protein modification process
  • performs the following molecular functions:
    • ATP binding
    • tubulin-tyrosine ligase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ttll1 indicates that it:
  • performs the following molecular functions:
    • ligase activity
  • is located in the following cellular components:
    • cytoplasm
    • cytoskeleton
    • microtubule
• Annotations directly to for the gene Ttll1 indicate that MGI curators have found no experimental data [literature] to support further annotation to these categories at this time.

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References

1. Ikegami K et al. (2007) Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc Natl Acad Sci U S A, 104:3213-8. (PubMed:17360631)
2. Ikegami K et al. (2010) Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry. Proc Natl Acad Sci U S A, 107:10490-5. (PubMed:20498047)
3. Vogel P et al. (2010) Tubulin tyrosine ligase-like 1 deficiency results in chronic rhinosinusitis and abnormal development of spermatid flagella in mice. Vet Pathol, 47:703-12. (PubMed:20442420)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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