Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables double-stranded DNA binding activity; double-stranded RNA binding activity; and single-stranded RNA binding activity. Involved in several processes, including innate immune response; positive regulation of cytokine production; and response to virus. Acts upstream of or within response to exogenous dsRNA. Predicted to be located in actin cytoskeleton; bicellular tight junction; and ruffle membrane. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm. Is expressed in several structures, including foregut; olfactory epithelium; ovary; renal calyx; and submandibular gland primordium. Orthologous to human RIGI (RNA sensor RIG-I).