Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Brip1. (This text reflects annotations as of Wednesday, August 14, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Brip1:
  • participates in the following biological processes:
    • negative regulation of cell proliferation
    • regulation of transcription from RNA polymerase II promoter
  • is located in the following cellular components:
    • cytoplasm
    • nuclear membrane
    • nucleus

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Summary text based on GO annotations supported by structural data

• Brip1 encodes a protein or proteins that contain the following InterPro domains: ATP-dependent helicase, C-terminal, DEAD2, DNA helicase (DNA repair), Rad3 type, Helicase, superfamily 1/2, ATP-binding domain, Helicase, superfamily 1/2, ATP-binding domain, DinG/Rad3-type, P-loop containing nucleoside triphosphate hydrolase, indicating that the gene product:
  • participates in the following biological processes:
    • nucleobase-containing compound metabolic process
  • performs the following molecular functions:
    • ATP binding
    • ATP-dependent DNA helicase activity
    • ATP-dependent helicase activity
    • DNA binding
    • hydrolase activity, acting on acid anhydrides
    • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    • nucleic acid binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Brip1 indicates that it:
  • participates in the following biological processes:
    • DNA repair
    • response to DNA damage stimulus
  • performs the following molecular functions:
    • 4 iron, 4 sulfur cluster binding
    • ATP binding
    • helicase activity
    • hydrolase activity
    • iron-sulfur cluster binding
    • metal ion binding
    • nucleotide binding

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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