Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dars2. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. It is a mitochondrial enzyme that specifically aminoacylates aspartyl-tRNA. Mutations in this gene are associated with leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL). [provided by RefSeq, Nov 2009]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Dars2
  • is located in the following cellular components:
    • mitochondrion ^[1]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Dars2:
  • participates in the following biological processes:
    • tRNA aminoacylation
  • performs the following molecular functions:
    • aspartate-tRNA(Asn) ligase activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • mitochondrion
    • nucleus

---

Summary text based on GO annotations supported by structural data

• Dars2 encodes a protein or proteins that contain the following InterPro domains: Aminoacyl-tRNA synthetase, class II, Aminoacyl-tRNA synthetase, class II (D/K/N), Aminoacyl-tRNA synthetase, class II (D/K/N)-like, Aspartate-tRNA ligase, class IIb, bacterial/mitochondrial-type, Aspartyl/Asparaginyl-tRNA synthetase, class IIb, GAD domain, Nucleic acid binding, OB-fold, tRNA/helicase-type, Nucleic acid-binding, OB-fold, indicating that the gene product:
  • participates in the following biological processes:
    • tRNA aminoacylation for protein translation
  • performs the following molecular functions:
    • aminoacyl-tRNA ligase activity
    • ATP binding
    • ligase activity
    • nucleic acid binding
    • nucleotide binding
  • is located in the following cellular components:
    • cytoplasm

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Dars2 indicates that it:
  • participates in the following biological processes:
    • translation
  • performs the following molecular functions:
    • aminoacyl-tRNA ligase activity
    • ATP binding
    • ligase activity
    • nucleotide binding
• Dars2 has been associated with the Enzyme Commission numbers: 6.1.1.12, which implies that the gene product:
  • performs the following molecular functions:
    • aspartate-tRNA ligase activity

---

References

1. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---