Automated description from the Alliance of Genome Resources (Release 7.0.0)
Involved in negative regulation of protein secretion. Acts upstream of or within protein localization to plasma membrane. Located in endoplasmic reticulum membrane and plasma membrane. Used to study palmoplantar keratoderma-esophageal carcinoma syndrome. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF2 (rhomboid 5 homolog 2).