GO curators for mouse genes have assigned the following annotations to the gene product of Lrrtm1. (This text reflects annotations as of Wednesday, August 14, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of July 26, 2013. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.Summary text based on GO annotations supported by experimental evidence in mouse
Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lrrtm1
participates in the following biological processes:
Annotations directly to molecular function for the gene Lrrtm1 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.
Ko J et al. (2011) Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol, 194:323-34. (PubMed:21788371)
Linhoff MW et al. (2009) An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron, 61:734-49. (PubMed:19285470)
Takashima N et al. (2011) Impaired cognitive function and altered hippocampal synapse morphology in mice lacking lrrtm1, a gene associated with schizophrenia. PLoS One, 6:e22716. (PubMed:21818371)
Voikar V et al. (2013) LRRTM1-deficient mice show a rare phenotype of avoiding small enclosures--a tentative mouse model for claustrophobia-like behaviour. Behav Brain Res, 238:69-78. (PubMed:23089646)