Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lrrtm1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of May 9, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lrrtm1
  • participates in the following biological processes:
    • behavior ^[3]
    • protein localization to synapse ^[2]
    • synapse organization ^{[2, 3]}
• Researchers have inferred, based on genetic interactions, that the gene product of Lrrtm1
  • participates in the following biological processes:
    • synapse organization based on interactions with Lrrtm2, Nlgn1, Nlgn3 ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lrrtm1:
  • participates in the following biological processes:
    • synapse organization
  • is located in the following cellular components:
    • axon
    • endoplasmic reticulum
    • excitatory synapse
    • growth cone
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lrrtm1 indicates that it:
  • is located in the following cellular components:
    • cell junction
    • membrane
    • plasma membrane
    • postsynaptic membrane
    • synapse
• Annotations directly to molecular function for the gene Lrrtm1 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Ko J et al. (2011) Neuroligins/LRRTMs prevent activity- and Ca2+/calmodulin-dependent synapse elimination in cultured neurons. J Cell Biol, 194:323-34. (PubMed:21788371)
2. Linhoff MW et al. (2009) An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers. Neuron, 61:734-49. (PubMed:19285470)
3. Takashima N et al. (2011) Impaired cognitive function and altered hippocampal synapse morphology in mice lacking lrrtm1, a gene associated with schizophrenia. PLoS One, 6:e22716. (PubMed:21818371)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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