Automated description from the Alliance of Genome Resources
Exhibits RNA polymerase II distal enhancer sequence-specific DNA binding activity and pre-mRNA intronic binding activity. Involved in several processes, including RNA splicing; positive regulation of protein import into nucleus; and regulation of protein stability. Localizes to the nucleus. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions; amyotrophic lateral sclerosis type 10; and frontotemporal dementia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 10; and motor neuron disease. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; genitourinary system; and heart. Orthologous to human TARDBP (TAR DNA binding protein).