Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Gabrp. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Gabrp:
  • performs the following molecular functions:
    • GABA-A receptor activity

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Summary text based on GO annotations supported by structural data

• Gabrp encodes a protein or proteins that contain the following InterPro domains: Gamma-aminobutyric acid A receptor, Gamma-aminobutyric-acid A receptor pi subunit, Neurotransmitter-gated ion-channel, Neurotransmitter-gated ion-channel ligand-binding, Neurotransmitter-gated ion-channel transmembrane domain, Neurotransmitter-gated ion-channel, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • ion transport
    • transport
  • performs the following molecular functions:
    • extracellular ligand-gated ion channel activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • postsynaptic membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Gabrp indicates that it:
  • participates in the following biological processes:
    • chloride transport
    • ion transport
    • transport
  • performs the following molecular functions:
    • chloride channel activity
  • is located in the following cellular components:
    • cell junction
    • chloride channel complex
    • integral to membrane
    • membrane
    • plasma membrane
    • postsynaptic membrane
    • synapse

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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