Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pex6. (This text reflects annotations as of Wednesday, August 14, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. [provided by RefSeq, Oct 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• The gene product of Pex6 has been shown to bind to the gene products of Smad2. ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pex6:
  • participates in the following biological processes:
    • ATP catabolic process
    • peroxisome organization
    • protein import into peroxisome matrix, translocation
    • protein stabilization
    • protein targeting to peroxisome
  • performs the following molecular functions:
    • ATP binding
    • ATPase activity
    • ATPase activity, coupled
    • protein C-terminus binding
    • protein complex binding
  • is located in the following cellular components:
    • cytoplasm
    • cytosol
    • peroxisomal membrane
    • peroxisome

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Summary text based on GO annotations supported by structural data

• Pex6 encodes a protein or proteins that contain the following InterPro domains: AAA+ ATPase domain, ATPase, AAA-type, conserved site, ATPase, AAA-type, core, P-loop containing nucleoside triphosphate hydrolase, indicating that the gene product:
  • performs the following molecular functions:
    • nucleoside-triphosphatase activity
    • nucleotide binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pex6 indicates that it:
  • performs the following molecular functions:
    • nucleotide binding
  • is located in the following cellular components:
    • membrane

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References

1. Warner DR et al. (2003) Identification of novel Smad binding proteins. Biochem Biophys Res Commun, 312:1185-90. (PubMed:14651998)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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