Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable chromatin DNA binding activity. Involved in heart formation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neurogenesis. Acts upstream of or within negative regulation of MAPK cascade and skeletal muscle cell differentiation. Located in nuclear membrane. Is expressed in several structures, including heart; leg muscle; liver; nephric duct; and neural tube. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2).