Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cdc73. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cdc73
  • participates in the following biological processes:
    • cellular response to lipopolysaccharide ^[3]
• The gene product of Cdc73 has been shown to bind to the gene products of Leo1. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cdc73
  • participates in the following biological processes:
    • endodermal cell fate commitment ^[1]
    • negative regulation of transcription from RNA polymerase II promoter ^[1]
    • stem cell maintenance ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Cdc73:
  • participates in the following biological processes:
    • histone H2B ubiquitination
    • histone monoubiquitination
    • mRNA polyadenylation
    • negative regulation of cell proliferation
    • negative regulation of epithelial cell proliferation
    • negative regulation of fibroblast proliferation
    • negative regulation of G1/S transition of mitotic cell cycle
    • negative regulation of myeloid cell differentiation
    • negative regulation of transcription from RNA polymerase II promoter
    • positive regulation of mRNA 3'-end processing
    • positive regulation of transcription elongation from RNA polymerase II promoter
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of Wnt signaling pathway
    • protein destabilization
  • performs the following molecular functions:
    • RNA polymerase II core binding
  • is located in the following cellular components:
    • Cdc73/Paf1 complex
    • nucleus

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cdc73 indicates that it:
  • participates in the following biological processes:
    • cell cycle
    • transcription, DNA-templated
    • Wnt signaling pathway

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References

1. Ding L et al. (2009) A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity. Cell Stem Cell, 4:403-15. (PubMed:19345177)
2. Vethantham V et al. (2012) Dynamic loss of H2B ubiquitylation without corresponding changes in H3K4 trimethylation during myogenic differentiation. Mol Cell Biol, 32:1044-55. (PubMed:22252316)
3. Youn MY et al. (2007) hCTR9, a component of Paf1 complex, participates in the transcription of interleukin 6-responsive genes through regulation of STAT3-DNA interactions. J Biol Chem, 282:34727-34. (PubMed:17911113)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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