Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables ubiquitin protein ligase activity. Involved in neural tube closure. Acts upstream of or within several processes, including cell differentiation involved in embryonic placenta development; circulatory system development; and protein ubiquitination. Predicted to be active in nuclear speck. Is expressed in several structures, including extraembryonic component; genitourinary system; heart; hemolymphoid system gland; and lung. Orthologous to human HECTD1 (HECT domain E3 ubiquitin protein ligase 1).