Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Il23r. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Il23r:
  • participates in the following biological processes:
    • cytokine-mediated signaling pathway
    • interleukin-23-mediated signaling pathway
    • JAK-STAT cascade
    • leukocyte mediated immunity
    • negative regulation of interleukin-10 production
    • positive regulation of defense response to virus by host
    • positive regulation of interferon-gamma production
    • positive regulation of interleukin-12 production
    • positive regulation of T-helper 1 type immune response
    • response to interferon-gamma
    • response to lipopolysaccharide
  • performs the following molecular functions:
    • interleukin-23 binding
    • interleukin-23 receptor activity
  • is located in the following cellular components:
    • integral to plasma membrane
    • interleukin-23 receptor complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Il23r indicates that it:
  • participates in the following biological processes:
    • inflammatory response
    • innate immune response
  • is located in the following cellular components:
    • integral to membrane
    • membrane
    • plasma membrane

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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