Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Xpnpep1. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 9, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the cytosolic form of a metalloaminopeptidase that catalyzes the cleavage of the N-terminal amino acid adjacent to a proline residue. The gene product may play a role in degradation and maturation of tachykinins, neuropeptides, and peptide hormones. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Nov 2009]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Xpnpep1:
  • participates in the following biological processes:
    • bradykinin catabolic process
    • proteolysis
  • performs the following molecular functions:
    • aminopeptidase activity
    • manganese ion binding
    • metalloaminopeptidase activity
    • protein homodimerization activity
  • is located in the following cellular components:
    • cytoplasm
    • cytosol

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Summary text based on GO annotations supported by structural data

• Xpnpep1 encodes a protein or proteins that contain the following InterPro domains: Creatinase, Peptidase M24, structural domain, Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • cellular process
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Xpnpep1 indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • metallopeptidase activity
    • peptidase activity

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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