Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Prpf8. (This text reflects annotations as of Thursday, January 16, 2014.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of February 2, 2010. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Prpf8:
  • participates in the following biological processes:
    • mRNA splicing, via spliceosome
  • is located in the following cellular components:
    • catalytic step 2 spliceosome
    • U5 snRNP

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Summary text based on GO annotations supported by structural data

• Prpf8 encodes a protein or proteins that contain the following InterPro domains: JAB1/Mov34/MPN/PAD-1, Pre-mRNA-processing-splicing factor 8, Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding, Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding, PRO, C-terminal, PROCN, PRP8 domain IV core, Ribonuclease H-like domain, RNA recognition motif, spliceosomal PrP8, indicating that the gene product:
  • performs the following molecular functions:
    • nucleic acid binding
    • RNA binding
    • U5 snRNA binding
    • U6 snRNA binding
  • is located in the following cellular components:
    • spliceosomal complex

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Prpf8 indicates that it:
  • participates in the following biological processes:
    • mRNA processing
    • RNA splicing
  • performs the following molecular functions:
    • RNA binding
  • is located in the following cellular components:
    • nucleus
    • ribonucleoprotein complex
    • spliceosomal complex

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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