Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Arhgdia. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 [PubMed 8262133]).[supplied by OMIM, Jan 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Arhgdia
  • participates in the following biological processes:
    • regulation of catalytic activity ^[3]
    • regulation of protein localization ^[4]
    • Rho protein signal transduction ^[3]
  • performs the following molecular functions:
    • Rho GDP-dissociation inhibitor activity ^[3]
  • is located in the following cellular components:
    • immunological synapse ^[1]
• The gene product of Arhgdia has been shown to bind to the gene products of Rac3. ^[2]

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Summary text based on GO annotations supported by structural data

• Arhgdia encodes a protein or proteins that contain the following InterPro domains: Immunoglobulin E-set, Rho GDP-dissociation inhibitor domain, RHO protein GDP dissociation inhibitor, indicating that the gene product:
  • is located in the following cellular components:
    • cytoplasm

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Arhgdia indicates that it:
  • performs the following molecular functions:
    • GTPase activator activity
  • is located in the following cellular components:
    • cytoplasm

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References

1. Allenspach EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity, 15:739-50. (PubMed:11728336)
2. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
3. Yonemura S et al. (2004) Rho localization in cells and tissues. Exp Cell Res, 295:300-14. (PubMed:15093731)
4. Zalcman G et al. (1996) RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG. J Biol Chem, 271:30366-74. (PubMed:8939998)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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