Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables Rho GDP-dissociation inhibitor activity. Involved in regulation of synaptic vesicle cycle and semaphorin-plexin signaling pathway. Acts upstream of or within Rho protein signal transduction and regulation of protein localization. Located in immunological synapse and nucleus. Is active in Schaffer collateral - CA1 synapse. Is expressed in brain; early nephron; and heart. Used to study nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha).