Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Cys1. (This text reflects annotations as of Tuesday, May 21, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of December 26, 2012. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Cys1
  • is located in the following cellular components:
    • cilium axoneme ^{[3, 4]}
    • membrane raft ^[4]
    • microtubule basal body ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Cys1
  • participates in the following biological processes:
    • inner ear development ^[2]
    • kidney development ^[1]
  • is located in the following cellular components:
    • cilium axoneme ^[4]

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Cys1 indicates that it:
  • is located in the following cellular components:
    • cell projection
    • cilium
    • cytoplasm
    • cytoskeleton
    • membrane
    • plasma membrane
• Annotations directly to molecular function for the gene Cys1 indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Alcalay NI et al. (2008) Acceleration of polycystic kidney disease progression in cpk mice carrying a deletion in the homeodomain protein Cux1. Am J Physiol Renal Physiol, 295:F1725-34. (PubMed:18829740)
2. Cho H et al. (1991) The molecular and structural basis of hearing impairment in mice with the cpk mutant gene. Ann N Y Acad Sci, 630:262-4. (PubMed:1952600)
3. Hou X et al. (2002) Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease. J Clin Invest, 109:533-40. (PubMed:11854326)
4. Tao B et al. (2009) Cystin localizes to primary cilia via membrane microdomains and a targeting motif. J Am Soc Nephrol, 20:2570-80. (PubMed:19850956)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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