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Gene Ontology Classifications
dicer 1, ribonuclease type III

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Dicer1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Andl T et al. (2006) The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol, 16:1041-9. (PubMed:16682203)
  2. Bernstein E et al. (2003) Dicer is essential for mouse development. Nat Genet, 35:215-7. (PubMed:14528307)
  3. Bjorkgren I et al. (2012) Dicer1 ablation in the mouse epididymis causes dedifferentiation of the epithelium and imbalance in sex steroid signaling. PLoS One, 7:e38457. (PubMed:22701646)
  4. Bremer J et al. (2010) Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination. PLoS One, 5:e12450. (PubMed:20805985)
  5. Chen JA et al. (2011) Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop. Neuron, 69:721-35. (PubMed:21338882)
  6. Chen JF et al. (2008) Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A, 105:2111-6. (PubMed:18256189)
  7. Cheung TH et al. (2012) Maintenance of muscle stem-cell quiescence by microRNA-489. Nature, 482:524-8. (PubMed:22358842)
  8. Choi PS et al. (2008) Members of the miRNA-200 family regulate olfactory neurogenesis. Neuron, 57:41-55. (PubMed:18184563)
  9. De Pietri Tonelli D et al. (2008) miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development, 135:3911-21. (PubMed:18997113)
  10. Dugas JC et al. (2010) Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination. Neuron, 65:597-611. (PubMed:20223197)
  11. Flemr M et al. (2013) A retrotransposon-driven dicer isoform directs endogenous small interfering RNA production in mouse oocytes. Cell, 155:807-16. (PubMed:24209619)
  12. Friedman LM et al. (2009) MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A, 106:7915-20. (PubMed:19416898)
  13. Grivna ST et al. (2006) MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis. Proc Natl Acad Sci U S A, 103:13415-20. (PubMed:16938833)
  14. Hanina SA et al. (2010) Genome-wide identification of targets and function of individual MicroRNAs in mouse embryonic stem cells. PLoS Genet, 6:e1001163. (PubMed:20975942)
  15. Harfe BD et al. (2005) The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A, 102:10898-903. (PubMed:16040801)
  16. Harris KS et al. (2006) Dicer function is essential for lung epithelium morphogenesis. Proc Natl Acad Sci U S A, 103:2208-13. (PubMed:16452165)
  17. Hornstein E et al. (2005) The microRNA miR-196 acts upstream of Hoxb8 and Shh in limb development. Nature, 438:671-4. (PubMed:16319892)
  18. Huang V et al. (2012) Upregulation of Cyclin B1 by miRNA and its implications in cancer. Nucleic Acids Res, 40:1695-707. (PubMed:22053081)
  19. Kim BM et al. (2011) Regulation of mouse stomach development and Barx1 expression by specific microRNAs. Development, 138:1081-6. (PubMed:21307095)
  20. Kim BM et al. (2012) Non-canonical microRNAs miR-320 and miR-702 promote proliferation in Dgcr8-deficient embryonic stem cells. Biochem Biophys Res Commun, 426:183-9. (PubMed:22925886)
  21. Kim J et al. (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science, 317:1220-4. (PubMed:17761882)
  22. Kok KH et al. (2007) Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J Biol Chem, 282:17649-57. (PubMed:17452327)
  23. Liu X et al. (2012) Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell, 46:507-17. (PubMed:22503104)
  24. Lynn FC et al. (2007) MicroRNA expression is required for pancreatic islet cell genesis in the mouse. Diabetes, 56:2938-45. (PubMed:17804764)
  25. Michon F et al. (2010) Tooth morphogenesis and ameloblast differentiation are regulated by micro-RNAs. Dev Biol, 340:355-68. (PubMed:20102707)
  26. Otsuka M et al. (2007) Hypersusceptibility to vesicular stomatitis virus infection in Dicer1-deficient mice is due to impaired miR24 and miR93 expression. Immunity, 27:123-34. (PubMed:17613256)
  27. Pereira JA et al. (2010) Dicer in Schwann cells is required for myelination and axonal integrity. J Neurosci, 30:6763-75. (PubMed:20463238)
  28. Repetto E et al. (2012) Let-7b/c enhance the stability of a tissue-specific mRNA during mammalian organogenesis as part of a feedback loop involving KSRP. PLoS Genet, 8:e1002823. (PubMed:22844247)
  29. Rybak A et al. (2008) A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol, 10:987-93. (PubMed:18604195)
  30. Sheehy NT et al. (2010) The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development, 137:4307-16. (PubMed:21098571)
  31. Spruce T et al. (2010) An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Dev Cell, 19:207-19. (PubMed:20708584)
  32. Tang F et al. (2007) Maternal microRNAs are essential for mouse zygotic development. Genes Dev, 21:644-8. (PubMed:17369397)
  33. Yang WJ et al. (2005) Dicer is required for embryonic angiogenesis during mouse development. J Biol Chem, 280:9330-5. (PubMed:15613470)
  34. Yi R et al. (2006) Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet, 38:356-62. (PubMed:16462742)
  35. Zheng GX et al. (2011) A latent pro-survival function for the mir-290-295 cluster in mouse embryonic stem cells. PLoS Genet, 7:e1002054. (PubMed:21573140)
  36. Zheng GX et al. (2011) Genome-wide impact of a recently expanded microRNA cluster in mouse. Proc Natl Acad Sci U S A, 108:15804-9. (PubMed:21911408)

Go Annotations in Tabular Form (Text View) (GO Graph)

Filter Markers by: Category  Evidence Code 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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