Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables pattern recognition receptor activity and transmembrane signaling receptor activity. Involved in several processes, including cellular response to virus; positive regulation of angiogenesis; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of cytokine production. Is active in plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; forebrain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3).