Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Involved in several processes, including mitochondrial DNA replication; negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; and nucleoside phosphate metabolic process. Predicted to localize to cytosol and nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B).