Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables DNA-directed DNA polymerase activity. Involved in double-strand break repair via alternative nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and somatic hypermutation of immunoglobulin genes. Acts upstream of or within DNA repair. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Is expressed in embryo; heart; spleen; and testis. Orthologous to human POLQ (DNA polymerase theta).