Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Strc. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that is associated with the hair bundle of the sensory hair cells in the inner ear. The hair bundle is composed of stiff microvilli called stereocilia and is involved with mechanoreception of sound waves. This gene is part of a tandem duplication on chromosome 15; the second copy is a pseudogene. Mutations in this gene cause autosomal recessive non-syndromic deafness. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Strc
  • is located in the following cellular components:
    • kinocilium ^[2]
    • stereocilium bundle tip ^{[1, 2]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Strc
  • participates in the following biological processes:
    • auditory receptor cell stereocilium organization ^{[1, 2]}
    • detection of mechanical stimulus involved in sensory perception of sound ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Strc:
  • participates in the following biological processes:
    • sensory perception of sound

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Strc indicates that it:
  • is located in the following cellular components:
    • cell projection
    • cilium
• Annotations directly to molecular function for the gene Strc indicate that MGI curators have found no experimental data [literature] to support further annotation to this category at this time.

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References

1. Verpy E et al. (2008) Stereocilin-deficient mice reveal the origin of cochlear waveform distortions. Nature, 456:255-8. (PubMed:18849963)
2. Verpy E et al. (2011) Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane. J Comp Neurol, 519:194-210. (PubMed:21165971)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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