Automated description from the Alliance of Genome Resources (Release 5.1.1)
Enables Toll-like receptor 2 binding activity; identical protein binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of NF-kappaB transcription factor activity; and regulation of cytokine production. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; positive regulation of tumor necrosis factor production; and response to bacterium. Located in endocytic vesicle and ruffle membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein).